We hope that this knowledge will translate to improved care in the coming years.” “This is an excellent opportunity to gain a better understanding of the genetic variants and molecular pathways that underlie CP or contribute to increased susceptibility to it. “Despite discovering CP in the 19th century, little progress has been made in understanding its causes,” Robinson said.
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JAX’s Peter Robinson, M.D., MSc., professor of computational biology who specializes in developing algorithms and software for the analysis of exome and genome sequences, will lead the computational analysis of the large set of data at JAX, an independent, nonprofit biomedical research institution. “The partnership with Peter Robinson and JAX lab provides the opportunity to learn more about the genetic causes of CP, which will certainly have an impact on clinical decision-making in the future, and perhaps someday facilitate the development of novel treatment paradigms that will minimize the musculoskeletal manifestations of this condition. This collaboration takes Shriners Hospitals for Children research on CP in a new and important direction I am honored to be part of the team on this innovative project.” Anita Bagley, Ph.D., co-director of the Motion Analysis Center at the Northern California Shriners Hospital, is Co-Investigator on the project. “The Shriners’ commitment to caring for tens of thousands of children has led to many advances in orthopaedic care (which focuses on the musculoskeletal manifestations of CP, such as gait disruption and hip dysplasia) over the years,” said Dr.
Davids, M.D., assistant chief of Orthopaedic Surgery, Shriners Hospitals for Children - Northern California, and Ben Ali Chair in Pediatric Orthopaedics at the University California at Davis. The detailed clinical and phenotypic characterization of the CP individuals will be led by Jon R. Kamran Shazand and his team from the SHC Genomics Institute laboratory in Tampa, Florida. Whole genome sequencing of the DNA samples will be performed via Illumina NovaSeq technology by Dr. Shriners Hospitals, which will provide data on the 500 patients, is well-positioned to play a leading role in this research due to the large number of children with CP that are treated throughout their health care system. All data analyzed in the study will be de-identified to ensure subjects’ privacy. The affiliation will apply clinical characterization and genome sequencing to a data set of 500 children affected by CP, as well as their parents, which represents the largest group of CP patients and their families ever to be investigated in this way. The condition, which describes a range of neurological disorders ranging in severity and symptoms from case-to-case, can impact coordination, cognitive function, muscle tone and balance.ĭespite CP’s prevalence, in most cases, its causes are still unclear, and there is no diagnostic test or effective therapy.īut whole genome sequencing (WGS) and analysis may provide important answers about the causes of this condition, potentially resulting in improved methods of diagnosis and treatment, and bringing hope to the many families affected by CP.Ī new research affiliation agreement between Shriners Hospitals for Children (SHC) and The Jackson Laboratory (JAX) will endeavor to gain greater understanding of the genetic factors involved in CP. 508 Compliance: Internal script disabled.TAMPA, Fla., Ap(GLOBE NEWSWIRE) - Cerebral palsy (CP) is the most common motor disability in childhood, affecting approximately one in every 500 children. 508 Compliance: Google Maps API script disabled. Our module pages support additional JS to fully function but still will be traversable.ĥ08 Compliance: jQuery Slick 1.6.0 script disabled. Universal-buttons.js, and slick-carousel 1.9.0. JQuery 3.2.1, Popper.js 1.14.3, Bootstrap 4.1.3, Google Translate, share-links.js, interface.js, member-tab.js, List of JavaScript dependencies not enabled: 508 Compliance: Internal universal buttons script disabled. 508 Compliance: Internal member-tab script disabled. 508 Compliance: Internal interface script disabled. 508 Compliance: Internal Share link script disabled. 508 Compliance: Google Translate disabled. 508 Compliance: bootstrap 4.1.3 disabled. 508 Compliance: popper.js 1.14.3 disabled. 508 Compliance: jQuery-3.2.1.min.js disabled.
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